The Liang Laboratory is dedicated to studying the molecular regulatory mechanisms of cellular phospholipid metabolism and its functional roles in physiology and disease. Liang Lab focuses on key processes including phospholipid synthesis, remodeling, and transport, and how these processes collectively shape membrane phospholipid composition and influence cellular functions. Liang Lab is particularly interested in how phospholipid metabolism contributes to membrane lipid homeostasis and regulates susceptibility to ferroptosis. Liang Lab's goal is to understand how phospholipid metabolic networks maintain a dynamic balance between normal cellular function and protection against lipid peroxidation–induced damage, and to explore their roles in cancer, neurodegenerative disorders, and metabolic diseases. Ultimately, Liang Lab aims to identify new therapeutic targets for disease intervention. To address these fundamental questions, Liang Lab focuses on the following research areas:

• Molecular basis of phospholipid metabolic state sensing and feedback regulation

• Molecular and metabolic mechanisms linking phospholipid metabolism to ferroptosis

• Functional roles and mechanisms of phospholipid metabolic reprogramming in tumor initiation and progression

• Molecular mechanisms by which dysregulated phospholipid metabolism contributes to metabolic and neurodegenerative diseases

• Therapeutic strategies targeting phospholipid metabolic pathways