sherif.badr(at)cimrbj.ac.cn
The Badr Laboratory at the Chinese Institutes for Medical Research (CIMR) is interested in understanding the fundamental mechanisms that maintain immune tolerance and prevent harmful self-reactivity. The lab's research focuses on autoreactive T cells and the molecular, cellular, and developmental pathways that determine their fate in health and disease. By integrating basic immunology with translational approaches, the lab aims to develop new therapeutic strategies for autoimmune diseases and cancer.
The lab's current research interests include:
1. Discovery of Clonal Eviction as a novel mechanism for autoreactive T cell tolerance — revealed that autoreactive CD8 T cells are not deleted in the thymus but instead prematurely exported as immature precursors that later differentiate into self-tolerant regulatory-like cells, redefining the classical view of central tolerance (Science, 2023).
2. Pathways controlling effector and helper T cell programming — identified CRTAM as a key driver of CD4⁺ cytotoxic T cell lineage commitment and uncovered nucleic acid sensing as a trigger for Th2 differentiation, providing new insights into how signals shape T cell fate (J Exp Med, 2016; Nat Commun, 2014).
3. Role of chemokine signaling in central tolerance — demonstrated how Sirpα⁺ dendritic cells and the chemokine receptor CCR2 orchestrate thymic tolerance and facilitate tumor immune evasion, highlighting the intersection of central tolerance and cancer biology (PLoS One, 2012).
Badr M#, Zhang Z, Tai X, Singer A#. CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus. Science, 2023, 382: 534–541. DOI: 10.1126/science.adh4124
Badr M, Hata K, Furuhata M, Toyota H, Yokosuka T. The multifaceted role of PD-1 in health and disease. In: Miyasaka M, Takatsu K (eds). Chronic Inflammation. Springer, Tokyo. 2016: 441–457.
Takeuchi A, Badr M, Miyauchi K, Ishihara C, Onishi R, Guo Z, Sasaki Y, Ike H, Takumi A, Tsuji N, Murakami Y, Katakai T, Kubo M, Saito T. CRTAM determines the CD4⁺ cytotoxic T lymphocyte lineage. J Exp Med, 2016, 213: 123–138. DOI: 10.1084/jem.20150519
Imanishi T, Ishihara C, Badr M, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T. Nucleic acid sensing by T cells initiates Th2 cell differentiation. Nat Commun, 2014, 5: 3566. DOI: 10.1038/ncomms4566
Baba T, Badr M, Tomaru U, Ishizu A, Mukaida N. Novel process of intrathymic tumor immune tolerance through CCR2-mediated recruitment of Sirpα⁺ dendritic cells: a murine model. PLoS One, 2012, 7: e41154. DOI: 10.1371/journal.pone.0041154
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
中文
