Rinkevich实验室研究旨在探索组织和器官受伤后的修复和再生过程,并致力于发现其背后的关键分子和细胞学机制,为临床治疗策略的开发提供科学支撑。
Correa-Gallegos D*, Ye H*, Dasgupta B*, Sardogan A, Kadri S, Kandi R, Dai R, Lin Y, Kopplin R, Shenai Disha S, Wannemacher J, Ichijo R, Jiang D, Strunz M, Ansari M, Angelidis I, Schiller H, Voltz T, Machens HG, Rinkevich Y. Spatiotemporal differentiation of CD201-expressing fascia progenitors choreographs injury repair. Nature, 2023, 623: 792-802. DOI: 10.1038/s41586-023-06725-x
Fischer A*, Correa-Gallegos D*, Wannemacher J, Christ S, Machens HG, Rinkevich Y. In vivo fluorescent labeling and tracking of Extracellular Matrix. Nature Protocols, 2023, 18: 2876-2890. DOI: 10.1038/s41596-023-00867-y
Gopal KS*, Dai R, Stefanska AM*, Ansari M, Zhao J, Ramesh P, Bagnoli JW, Correa-Gallegos D, Lin Y, Christ S, Angelidis I, Lupperger V, Marr C, Davies LC, Enard W, Machens HG, Schiller HB, Jiang D, Rinkevich Y. Wound infiltrating adipocytes are not myofibroblasts. Nature Communications, 2023, 14: 3020. DOI 10.1038/s41467-023-38591-6
Fischer A*, Wannemacher J*, Christ S*, Koopmans T, Kadri S, Zhao J, Gouda M, Ye H, Mück-Häusl M, Krenn PW, Machens HG, Fässler R, Neuman PA, Hauck S, Rinkevich Y. Neutrophils direct preexisting matrix in to initiate repair of damaged organs. Nature Immunology, 2022, 23: 518–531 DOI: 10.1038/s41590-022-01166-6
Jiang D*, Christ S*, Correa-Gallegos D*, Ramesh P*, Kalgudde Gopa S, Wannemacher J, Mayr C, Lupperger V, Yu Q, Ye H, Mück-Häusl M, Rajendran V, Wan L, Liu J, Mirastschijski U, Volz T, Marr C, Schiller H, Rinkevich Y. Fascia fibroblasts swarm to drive scar formation through N-cadherin. Nature Communications, 2020, 11: 5653 .DOI: 10.1038/s41467-020-19425-1
Fischer A*, Koopmans T*, Ramesh P, Christ S, Strunz M, Aichler M, Feuchtinger A, Walch A, Ansari M, Theis FJ, Schorpp K, Hadian K, Neumann PA, Schiller HB, Rinkevich Y. Post-surgical adhesions are caused by membrane bridges and fusions between mesothelial surfaces. Nature Communications, 2020, 11: 3068 DOI: 10.1038/s41467-020-16893-3
Correa-Gallegos D*, Jiang D*, Christ S, Ramesh P, Ye H, Wannemacher J, Kalgudde Gopal S, Yu Q, Aichler M, Walch A, Mirastschijski U, Volz T, Rinkevich Y. Patch repair of deep wounds by mobilized fascia. Nature, 2019, 576: 287-292 DOI: 10.1038/s41586-019-1794-y
Jiang D*, Correa-Gallegos D*, Christ S, Stefanska A, Liu J, Ramesh P, Rajendran V, Wagner D, Rinkevich Y . Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring. Nature Cell Biology, 2018, 20: 422-431. DOI: 10.1038/s41556-018-0073-8
Tsai JM*, Sinha R*, Seita J, Fernhoff N, Christ S, Koopmans T, Krampitz GW, McKenna KM, Xing L, Shoham M, McCracken M, Joubert LM, Gordon SR, Poux N, Wernig G, Norton JA, Sandholzer M, Sales J, Weissman IL, Rinkevich Y . Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers. Science Translational Medicine, 2018, 10: 469 DOI: 10.1126/scitranslmed.aan6735
Rinkevich Y*, Walmsley GG*, Hu MS*, Maan ZN*, Newman AM, Drukker M, Lorenz PH, Weissman IL, Longaker MT . Identification and Targeted inhibition of a Dermal Lineage Responsible for Scarring and Cancer Stroma. Science, 2015, 348: 420-431. DOI: 10.1126/science.aaa2151