hypiwl(at)163.com
黄亚平实验室主要研究热休克蛋白（也叫分子伴侣）HSP40家族的生理学功能，尤其在维持基因组稳定性、天然免疫和糖代谢途径中的功能和作用机制，及其在肿瘤、自体免疫疾病和代谢疾病中的作用。
1. 发现HSP40家族蛋白DNAJA2在维持基因组稳定性和肿瘤免疫治疗中的作用及机制（Nature Communications, 2023; Cell Discovery, 2023）
3．发现导致家族遗传性口腔癌的遗传基因突变（Cell Discovery, 2019）
Huang Y*, Lu C*, Wang H, Gu L, Fu YX#, Li GM#. DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. Nature Communications, 2023, 14: 5246. DOI: 10.1038/s41467-023-40952-0
Huang Y, Gu L, Li GM. Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy. Cell Discovery, 2023, 9: 107. DOI: 10.1038/s41421-023-00601-8
Huang Y*, Zhao J*, Mao G, Lee GS, Zhang J, Bi L, Gu L, Chang Z, Valentino J#, Li GM#. Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas. Cell Discovery, 2019, 5: 57. DOI: 10.1038/s41421-019-0126-6
Fang J*, Huang Y*, Mao G*, Yang S, Rennert G, Gu L, Li H, Li GM. Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction. Proceedings of the National Academy of Science of the United States of America, 2018, 115: 9598-9603. DOI: 10.1073/pnas.1806355115
Huang Y, Li GM. DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential. DNA Repair (Amst), 2020, 93: 102918. DOI: 10.1016/j.dnarep.2020.102918
Huang Y, Li GM. DNA mismatch repair preferentially safeguards actively transcribed genes. DNA Repair (Amst), 2018, 71: 82-86. DOI: 10.1016/j.dnarep.2018.08.010
Huang Y, Gu L, Li GM. H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation. Journal of Biological Chemistry, 2018, 293: 7811-7823. DOI: 10.1074/jbc.RA118.002839
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