fangwei.leng(at)cimrbj.ac.cn
冷方伟实验室从蛋白质互作、染色质三维结构及表观遗传修饰等方面系统研究调节性T细胞（Treg）的基因调控机理，并设计靶向关键蛋白如FoxP3的小分子、多肽药物和纳米抗体以调控调节性T细胞功能，开发自身免疫疾病和肿瘤治疗策略。
1. 揭示了FoxP3两种二聚化状态对调节性T细胞功能的影响（Immunity, 2022, 封面文章）。
Leng F*, Merino R*, Wang X, Zhang W, Ha T, Hur S. Ultrastable and Versatile FoxP3 Ensembles on Microsatellites. Molecular Cell, 2024, In press.
Zhang W*, Leng F*, Wang X, Ramirez R, Park J, Benoist C, Hur S. FoxP3 recognizes microsatellites and bridges DNA through multimerization. Nature, 2023, 624: 433-441. DOI: 10.1038/s41586-023-06793-z (Previewed in Nature, 2023, 624: 255-256)
Leng F*, Zhang W*, Ramirez RN, Leon J, Zhong Y, Hou L, Yuki K, van der Veeken J, Rudensky AY, Benoist C, Hur S. The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. Immunity, 2022, 55: 1354-1369.e8. DOI: 10.1016/j.immuni.2022.07.002 (Cover article; Previewed in Immunity, 2022, 55: 1329-1331)
Leng F*, Yin H*, Qin S, Zhang K, Guan Y, Fang R, Wang H, Li G, Jiang Z, Sun F, Wang DC, Xie C. NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation. Sci Rep, 2020, 10: 198. DOI: 10.1038/s41598-019-57043-0
Leng F, Xie C, Wang DC. Structure and self-assembly of NLRP10. Progress in Biochemistry and Biophysics, 2015, 42: 1112-1118. DOI: 10.16476/j.pibb.2015.0306
Leng F. Build a two-way road for health industry: the current circumstance of translational medicine in China. Sci China Life Sci, 2012, 55: 931-932. DOI: 10.1007/s11427-012-4377-9
Leng F. Opportunity and challenge: ten years of proteomics in China. Sci China Life Sci, 2012, 55: 837-839. DOI: 10.1007/s11427-012-4372-1
Leng F. On Ca2+ signalling research. Sci China Life Sci, 2012, 55: 744-746. DOI: 10.1007/s11427-012-4358-z
Leng F. Recent progress of immunology research in China. Sci China Life Sci, 2011, 54: 1068-1070. DOI: 10.1007/s11427-011-4248-9
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