李凯实验室研究细胞器生理稳态的调控机制,尤其关注溶酶体离子稳态平衡的维持机制、生理功能和病理意义,并在此基础上开发靶向细胞器的治疗方法。
1. 发现溶酶体具有机械力感受特性并鉴定溶酶体机械感受离子通道(Nature Cell Biology, 2024; Trends in Cell Biology, 2025)
3. 解析内质网中钾离子通道亚基聚合的分子机制(Molecular Cell, 2017; Journal of General Physiology, 2018)
4. 鉴定可以矫正异常离子通道功能的小分子化合物 (Nature Communications, 2018)
Li K*, Guo Y*, Wang Y*, Zhu R, Chen W, Cheng T, Zhang X, Jia Y, Liu T, Zhang W, Jan LY, Jan YN. Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels. Nature Cell Biology, 2024, 26: 393–403. DOI: 10.1038/s41556-024-01353-7
Li K#, Cai S-Q#. The Biosynthesis and Folding of Oily Peptide Chains. Advances in Membrane Proteins, 2019, Springer, Chapter 5: 85-109. DOI: 10.1007/978-981-13-9077-7
Bai X*, Li K*, Yao L, Kang XL, Cai S-Q. A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K+ channels. Journal of General Physiology, 2018, 150: 1189-1201. DOI: 10.1085/jgp.201812025
Jiang Q*, Li K*, Lu W-J, Li S, Chen X, Liu X-J, Yuan J, Ding Q, Lan F, Cai S-Q. Identification of small-molecule ion channel modulators in C. elegans channelopathy models. Nature Communications, 2018, 9: 3941. DOI: 10.1038/s41467-018-06514-5
Li K*, Jiang Q*, Bai X, Yang Y-F, Ruan M-Y, Cai S-Q. Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins. Molecular Cell, 2017, 65: 52-65. DOI: 10.1016/j.molcel.2016.10.027
Yin J-A, Gao G, Liu X-J, Hao Z-Q, Li K, Kang X-L, Li H, Shan Y-H, Li H-P, Cai S-Q. Genetic variation in glia–neuron signaling modulates ageing rate. Nature, 2017, 551: 198-203. DOI: 10.1038/nature24463