首都医学科学创新中心-邓子厚

研究人员

邓子厚

zdeng(at)cimrbj.ac.cn

研究员

zdeng(at)cimrbj.ac.cn

华中师范大学生命科学学士

中国科学院上海巴斯德研究所微生物学博士

工作经历

2024.6

首都医学科学创新中心研究员

2021.8-2024.6

纪念斯隆-凯特林癌症中心资深科学家

2016.8-2021.7

纪念斯隆-凯特林癌症中心博士后

研究方向

邓子厚实验室研究免疫系统在肿瘤、组织损伤、神经退行性疾病等疾病过程中的功能及调控机制，尤其关注巨噬细胞在这些疾病发生过程中的作用机制，并在此基础上开发新的治疗方法。

主要研究课题

1. 巨噬细胞在包括肿瘤、组织损伤等疾病过程中的功能及作用机制

2. 肿瘤免疫逃逸的分子机制

3. 增强肿瘤免疫治疗的新靶点开发

主要成果与贡献

1. 发现核因子ID3调控巨噬细胞抗肿瘤机制。（Nature，2024）

2. 发现SHP2调控宿主抗真菌感染机制。（Nature Immunology，2015）

代表性文章

Deng Z, Loyher PL, Lazarov T, Li L, Shen Z, Bhinder B, Yang H, Alberdi A, Massague J, Sun J, Benezra R, Glass CK, Elemento O, Iacobuzio-Donahue CA, Geissmann F#. The nuclear factor ID3 endows macrophages with a potent anti-tumor activity. Nature. 2024 Feb 7. DOI: 10.1038/s41586-023-06950-4

Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H^#. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T_H17 responses. Nature Immunology, 2015, 16: 642-652. DOI: 10.1038/ni.3155

Sakai M*, Troutman T D*., Seidman J S*., Ouyang Z,. Spann NJ, AbeY, Ego KM, Bruni CM, Deng Z, Schlachetzki JCM, Nott A, Bennett H, Chang J, Vu BCT, Pasillas MP, Link VM, Texari L, Heinz S, Thompson BM, McDonald JG, Geissmann F, and Glass CK^#. Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity. Immunity, 2019, 51: 655-670.e8. DOI: 10.1016/j.immuni.2019.09.002

Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H^#, Chen J^#. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nature Communication. 10: 1015. DOI: 10.1038/s41467-019-08950-3

Loyher PL*, Hamon P*, Laviron M, Meghraoui-Kheddar A, Goncalves E, Deng Z, Torstensson S, Bercovici N, Baudesson de Chanville C, Combadière B, Geissmann F, Savina A, Combadière C, Boissonnas A^#. Macrophages of distinct origins contribute to tumor development in the lung. Journal of Experimental Medicine, 2018, 215: 2536- 2553.DOI: 10.1084/jem.20180534

Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H^#. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. Journal of Experimental Medicine, 2017, 214:1471-1491. DOI: 10.1084/jem.20161149

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