qdeng(at)cimrbj.ac.cn
邓庆实验室致力于解析调控B细胞命运与功能的表观遗传调控网络。实验室研究整合免疫学、染色质生物学及转化医学，旨在揭示基因调控程序如何塑造保护性免疫、自身免疫及恶性转化。通过阐明B细胞可塑性背后的分子逻辑，实验室力求建立免疫重编程的新范式，并为淋巴瘤、自身免疫病及其他免疫介导疾病开发变革性疗法。
1. 鉴定SWI/SNF染色质重塑复合物的突变基因及其调控肿瘤细胞恶性特征和命运决定的分子机制（Cancer Cell, 2024; Nature Genetics, 2012）
2. 揭示与CD19 CAR-T细胞治疗复发或难治性大B细胞淋巴瘤的疗效和毒性相关的细胞分子特征（Nature Medicine, 2020; Cell Reports Medicine, 2023; Cancer Cell, 2023; Blood Advances, 2023）
3. 表征多种B细胞淋巴瘤亚型的肿瘤微环境，特别关注与肿瘤细胞突变和抗原呈递机制相关的生物学特征以及对CD19 CAR-T细胞治疗的反应（Blood Cancer Discovery, 2022; Cancer Cell, Under Review）
Deng Q*, Lakra P*, Gou P*, Yang H, Meydan C, Teater M, Chin CR, Li X, Rojas-Neira E, Liu W, Reville P, Kizhakeyli A, Parsons S, Wilson A, Herderson J, Scull B, Gurumurthy G, Vega F, Chadburn A, Cuglievan B, El-Mallawany N, Allen C, Mason CE, Melnick A, Green MR. Smarca4 is a haploinsufficient B-cell tumor suppressor that fine-tunes centrocyte cell fate decisions. Cancer Cell, 2024, 42: 605-622.e11. DOI: 10.1016/j.ccell.2024.02.011
Strati P*, Li X*, Deng Q*, Marques-Piubelli M, Henderson J, Balada G, Deaton L, Cain T, Yang H, Ravanmehr V, Fayad L, Iyer S, Nastoupil L, Hagemeister F, Fowler N, Westin J, Steiner R, Nair R, Flowers C, Wang L, Ahmed S, Al-Atrash G, Vega F, Neelapu S#, Green MR#. Prolonged cytopenia following CD19 CAR T cell therapy is linked with bone marrow infiltration of clonally expanded IFNγ-expressing CD8 T cells. Cell Reports Medicine, 2023, 4: 101158. DOI: 10.1016/j.xcrm.2023.101158
Han G*, Deng Q*, Marques-Piubelli ML, Dai E, Dang M, Ma MCJ, Li X, Yang H, Henderson J, Kudryashova O, Meerson M, Isaev S, Kotlov N, Nomie KJ, Bagaev A, Parra ER, Solis Soto LM, Parmar S, Hagemeister FB, Ahmed S, Iyer SP, Samaniego F, Steiner R, Fayad L, Lee H, Fowler NH, Flowers CR, Strati P, Westin JR, Neelapu SS, Nastoupil LJ, Vega F, Wang L#, Green MR#. Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression. Blood Cancer Discovery, 2022, 3: 428-443. DOI: 10.1158/2643-3230.BCD-21-0075
Li X, Henderson J, Gordon M, Sheikh I, Nastoupil L, Westin J, Flowers C, Ahmed S, Wang L, Neelapu S, Strati P, Deng Q#, Green MR#. A single-cell atlas of CD19 chimeric antigen receptor T cells. Cancer Cell, 2023, 41: 1835-1837. DOI: 10.1016/j.ccell.2023.08.015
Deng Q*, Han G*, Puebla-Osorio N, Ma M, Strati P, Chasen B, Jain N, Yang H, Wang Y, Zhang S, Wang R, Chen R, Showell J, Ghosh S, Patchva S, Zhang Q, Dai E, Hagemeister F, Fayad L, Saminiego F, Lee H, Nastoupil L, Fowler N, Davis R, Westin J, Neelapu S#, Wang L#, Green MR#. Characteristics of anti-CD19 CAR T-cell infusion products associated with efficacy and toxicity in patients with large B-cell lymphomas. Nature Medicine, 2020, 26: 1878-1887. DOI: 10.1038/s41591-020-1061-7
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